Vitamin D is sometimes called a “super” vitamin because of its many reported benefits. In addition to these many benefits, Vitamin D also helps support a healthy mood and brain.

Studies Show Vitamin D Supplementation Improved Mood Scores.

A study of over 111 people who received vitamin D supplementation for six months found significantly improved mood scores correlating with supplementation. After vitamin D supplementation stopped, researchers found these scores worsened as vitamin D levels in subjects declined (2).

A study with 441 people evaluated the effects of vitamin D on mood versus placebo. After one year, those receiving vitamin D showed a significant improvement in mood evaluation scoring compared to placebo. The authors of this study conclude there appears to be a correlation with vitamin D levels and symptoms of poor mood (3).

Vitamin D Deficiency Is Associated With Anxiety & Poor Mood.

A published review found a significant association between mood disorders and vitamin D deficiency in 4 of 6 studies that were evaluated. The authors of the review believe this association may be linked to the presence of vitamin D receptors in the brain. Receptors not adequately filled may possibly interfere with normal brain biological processes (1).

A study published in 2021 found 49 out of 50 patients with obsessive compulsive disorder (OCD) who were selected were deficient in vitamin D. Researchers of this study conclude vitamin D levels may possibly be related to severity of OCD symptoms (4).

A 2015 study divided 200 people into male and female groups. Each of these groups were further divided into 1) those with an anxiety disorder, 2) those with a mood disorder, and 3) those with neither. Researchers found significantly lower blood levels of vitamin D in all anxiety and mood disorder groups (both male and female). Those who did not have an anxiety or mood disorder were found to have normal vitamin D levels (5).

A study of 30 patients with anxiety disorder who were being treated at an inpatient unit were divided into 2 groups. One group received standard care while the second group received vitamin D supplementation in addition to standard care. At the end of the 3 months, the group receiving vitamin D experienced significant improvement on anxiety score testing while the group receiving standard care alone did not (6).


1) Murphy, P. K., &; Wagner, C. L. (2008). Vitamin D and mood disorders among women: An integrative review. Journal of Midwifery & Women’s Health, 53(5), 440–446.
2) Stokes, C. S., Grünhage, F., Baus, C., Volmer, D. A., Wagenpfeil, S., Riemenschneider, M., &; Lammert, F. (2016). Vitamin D supplementation reduces depressive symptoms in patients with chronic liver disease. Clinical Nutrition, 35(4), 950–957.
3) Jorde, R., Sneve, M., Figenschau, Y., Svartberg, J., &; Waterloo, K. (2008). Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: Randomized double blind trial. Journal of Internal Medicine, 264(6), 599–609.
4) Marazziti, D., Barberi, F. M., Fontenelle, L., Buccianelli, B., Carbone, M. G., Parra, E., Palermo, S., Massa, L., Tagliarini, C., Della Vecchia, A., Mucci, F., Arone, A., & Dell’Osso, L. (2021). Decreased vitamin D levels in obsessive-compulsive disorder patients. CNS Spectrums, 1–8.
5) BIČÍKOVÁ, M., DUŠKOVÁ, M., VÍTKŮ, J., KALVACHOVÁ, B., ŘÍPOVÁ, D., MOHR, P., &; STÁRKA, L. (2015). Vitamin D in anxiety and affective disorders. Physiological Research.
6) Eid, A., Khoja, S., AlGhamdi, S., Alsufiani, H., Alzeben, F., Alhejaili, N., Tayeb, H. O., &; Tarazi, F. I. (2019). Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD). Metabolic Brain Disease, 34(6), 1781–1786.